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Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.


ABSTRACT: Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in European-ancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to 17,110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3 , CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI. Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci. Our study provides additional insight on genetic contribution to abdominal obesity.

SUBMITTER: Wen W 

PROVIDER: S-EPMC4726286 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.

Wen Wanqing W   Kato Norihiro N   Hwang Joo-Yeon JY   Guo Xingyi X   Tabara Yasuharu Y   Li Huaixing H   Dorajoo Rajkumar R   Yang Xiaobo X   Tsai Fuu-Jen FJ   Li Shengxu S   Wu Ying Y   Wu Tangchun T   Kim Soriul S   Guo Xiuqing X   Liang Jun J   Shungin Dmitry D   Adair Linda S LS   Akiyama Koichi K   Allison Matthew M   Cai Qiuyin Q   Chang Li-Ching LC   Chen Chien-Hsiun CH   Chen Yuan-Tsong YT   Cho Yoon Shin YS   Choi Bo Youl BY   Gao Yutang Y   Go Min Jin MJ   Gu Dongfeng D   Han Bok-Ghee BG   He Meian M   Hixson James E JE   Hu Yanling Y   Huang Tao T   Isono Masato M   Jung Keum Ji KJ   Kang Daehee D   Kim Young Jin YJ   Kita Yoshikuni Y   Lee Juyoung J   Lee Nanette R NR   Lee Jeannette J   Wang Yiqin Y   Liu Jian-Jun JJ   Long Jirong J   Moon Sanghoon S   Nakamura Yasuyuki Y   Nakatochi Masahiro M   Ohnaka Keizo K   Rao Dabeeru D   Shi Jiajun J   Sull Jae Woong JW   Tan Aihua A   Ueshima Hirotsugu H   Wu Chen C   Xiang Yong-Bing YB   Yamamoto Ken K   Yao Jie J   Ye Xingwang X   Yokota Mitsuhiro M   Zhang Xiaomin X   Zheng Yan Y   Qi Lu L   Rotter Jerome I JI   Jee Sun Ha SH   Lin Dongxin D   Mohlke Karen L KL   He Jiang J   Mo Zengnan Z   Wu Jer-Yuarn JY   Tai E Shyong ES   Lin Xu X   Miki Tetsuro T   Kim Bong-Jo BJ   Takeuchi Fumihiko F   Zheng Wei W   Shu Xiao-Ou XO  

Scientific reports 20160120


Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in European-ancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to 17,110 additional individu  ...[more]

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