Ontology highlight
ABSTRACT:
SUBMITTER: Leal-Pinto E
PROVIDER: S-EPMC3000960 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Leal-Pinto Edgar E Gómez-Llorente Yacob Y Sundaram Shobana S Tang Qiong-Yao QY Ivanova-Nikolova Tatyana T Mahajan Rahul R Baki Lia L Zhang Zhe Z Chavez Jose J Ubarretxena-Belandia Iban I Logothetis Diomedes E DE
The Journal of biological chemistry 20101006 51
Kir3 channels control heart rate and neuronal excitability through GTP-binding (G) protein and phosphoinositide signaling pathways. These channels were the first characterized effectors of the βγ subunits of G proteins. Because we currently lack structures of complexes between G proteins and Kir3 channels, their interactions leading to modulation of channel function are not well understood. The recent crystal structure of a chimera between the cytosolic domain of a mammalian Kir3.1 and the trans ...[more]