Ontology highlight
ABSTRACT:
SUBMITTER: Vitezic M
PROVIDER: S-EPMC3001087 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Vitezic Morana M Lassmann Timo T Forrest Alistair R R AR Suzuki Masanori M Tomaru Yasuhiro Y Kawai Jun J Carninci Piero P Suzuki Harukazu H Hayashizaki Yoshihide Y Daub Carsten O CO
Nucleic acids research 20100819 22
Perturbation and time-course data sets, in combination with computational approaches, can be used to infer transcriptional regulatory networks which ultimately govern the developmental pathways and responses of cells. Here, we individually knocked down the four transcription factors PU.1, IRF8, MYB and SP1 in the human monocyte leukemia THP-1 cell line and profiled the genome-wide transcriptional response of individual transcription starting sites using deep sequencing based Cap Analysis of Gene ...[more]