Ontology highlight
ABSTRACT:
SUBMITTER: Roy S
PROVIDER: S-EPMC4538831 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Roy Sugata S Schmeier Sebastian S Arner Erik E Alam Tanvir T Parihar Suraj P SP Ozturk Mumin M Tamgue Ousman O Kawaji Hideya H de Hoon Michiel J L MJ Itoh Masayoshi M Lassmann Timo T Carninci Piero P Hayashizaki Yoshihide Y Forrest Alistair R R AR Bajic Vladimir B VB Guler Reto R Brombacher Frank F Suzuki Harukazu H
Nucleic acids research 20150627 14
Classically or alternatively activated macrophages (M1 and M2, respectively) play distinct and important roles for microbiocidal activity, regulation of inflammation and tissue homeostasis. Despite this, their transcriptional regulatory dynamics are poorly understood. Using promoter-level expression profiling by non-biased deepCAGE we have studied the transcriptional dynamics of classically and alternatively activated macrophages. Transcription factor (TF) binding motif activity analysis reveale ...[more]