Ontology highlight
ABSTRACT:
SUBMITTER: Clem RL
PROVIDER: S-EPMC3001394 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Clem Roger L RL Huganir Richard L RL
Science (New York, N.Y.) 20101028 6007
Traumatic fear memories can be inhibited by behavioral therapy for humans, or by extinction training in rodent models, but are prone to recur. Under some conditions, however, these treatments generate a permanent effect on behavior, which suggests that emotional memory erasure has occurred. The neural basis for such disparate outcomes is unknown. We found that a central component of extinction-induced erasure is the synaptic removal of calcium-permeable α-amino-3-hydroxyl-5-methyl-4-isoxazole-pr ...[more]