Structure of Plasmodium falciparum ADP-ribosylation factor 1.
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ABSTRACT:
SUBMITTER: Cook WJ
PROVIDER: S-EPMC3001640 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Publications
Structure of Plasmodium falciparum ADP-ribosylation factor 1.
Cook William J WJ Smith Craig D CD Senkovich Olga O Holder Anthony A AA Chattopadhyay Debasish D
Acta crystallographica. Section F, Structural biology and crystallization communications 20101027 Pt 11
Vesicular trafficking may play a crucial role in the pathogenesis and survival of the malaria parasite. ADP-ribosylation factors (ARFs) are among the major components of vesicular trafficking pathways in eukaryotes. The crystal structure of ARF1 GTPase from Plasmodium falciparum has been determined in the GDP-bound conformation at 2.5 Å resolution and is compared with the structures of mammalian ARF1s. ...[more]
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