Ontology highlight
ABSTRACT:
SUBMITTER: Popoff V
PROVIDER: S-EPMC3195608 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Popoff Vincent V Langer Julian D JD Reckmann Ingeborg I Hellwig Andrea A Kahn Richard A RA Brügger Britta B Wieland Felix T FT
The Journal of biological chemistry 20110815 41
Newly synthesized proteins and lipids are transported in vesicular carriers along the secretory pathway. Arfs (ADP-ribosylation factors), a family of highly conserved GTPases within the Ras superfamily, control recruitment of molecular coats to membranes, the initial step of coated vesicle biogenesis. Arf1 and coatomer constitute the minimal cytosolic machinery leading to COPI vesicle formation from Golgi membranes. Although some functional redundancies have been suggested, other Arf isoforms ha ...[more]