Ontology highlight
ABSTRACT:
SUBMITTER: Lamorde M
PROVIDER: S-EPMC3001850 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Lamorde Mohammed M Byakika-Kibwika Pauline P Okaba-Kayom Violet V Ryan Mairin M Coakley Peter P Boffito Marta M Namakula Rhoda R Kalemeera Francis F Colebunders Robert R Back David D Khoo Saye S Merry Concepta C
The Journal of antimicrobial chemotherapy 20101102 1
<h4>Background</h4>rifampicin lowers nevirapine plasma concentrations by inducing cytochrome P450. However, few data are available on this interaction during the lead-in period of nevirapine treatment.<h4>Methods</h4>eighteen HIV-1/tuberculosis co-infected adults receiving rifampicin daily as part of anti-tuberculosis therapy were evenly randomized to nevirapine initiation by dose escalation (NVP200) or nevirapine initiation at 200 mg twice daily (NVP400). Subjects underwent 12 h intensive pharm ...[more]