Ontology highlight
ABSTRACT:
SUBMITTER: Duose DY
PROVIDER: S-EPMC3002180 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Duose Dzifa Y DY Schweller Ryan M RM Hittelman Walter N WN Diehl Michael R MR
Bioconjugate chemistry 20101116 12
A class of reactive DNA circuits was adapted as erasable molecular imaging probes that allow fluorescent reporting complexes to be assembled and disassembled on a biological specimen. Circuit reactions are sequence-dependent and therefore facilitate multiplexed (multicolor) detection. Yet, the ability to disassemble reporting complexes also allows fluorophores to be removed and new circuit complexes to be used to label additional markers. Thus, these probes present opportunities to increase the ...[more]