Ontology highlight
ABSTRACT:
SUBMITTER: Alves DS
PROVIDER: S-EPMC3002392 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Alves Daiane S DS Farr Glen A GA Seo-Mayer Patricia P Caplan Michael J MJ
Molecular biology of the cell 20101013 24
The Na(+),K(+)-ATPase is the major active transport protein found in the plasma membranes of most epithelial cell types. The regulation of Na(+),K(+)-ATPase activity involves a variety of mechanisms, including regulated endocytosis and recycling. Our efforts to identify novel Na(+),K(+)-ATPase binding partners revealed a direct association between the Na(+),K(+)-ATPase and AS160, a Rab-GTPase-activating protein. In COS cells, coexpression of AS160 and Na(+),K(+)-ATPase led to the intracellular r ...[more]