Ontology highlight
ABSTRACT:
SUBMITTER: Kirshenbaum GS
PROVIDER: S-EPMC3207708 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Kirshenbaum Greer S GS Clapcote Steven J SJ Duffy Steven S Burgess Christian R CR Petersen Janne J Jarowek Karolina J KJ Yücel Yeni H YH Cortez Miguel A MA Snead O Carter OC Vilsen Bente B Peever John H JH Ralph Martin R MR Roder John C JC
Proceedings of the National Academy of Sciences of the United States of America 20111024 44
Bipolar disorder is a debilitating psychopathology with unknown etiology. Accumulating evidence suggests the possible involvement of Na(+),K(+)-ATPase dysfunction in the pathophysiology of bipolar disorder. Here we show that Myshkin mice carrying an inactivating mutation in the neuron-specific Na(+),K(+)-ATPase α3 subunit display a behavioral profile remarkably similar to bipolar patients in the manic state. Myshkin mice show increased Ca(2+) signaling in cultured cortical neurons and phospho-ac ...[more]