Ontology highlight
ABSTRACT:
SUBMITTER: Trichonas G
PROVIDER: S-EPMC3003048 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Trichonas George G Murakami Yusuke Y Thanos Aristomenis A Morizane Yuki Y Kayama Maki M Debouck Christine M CM Hisatomi Toshio T Miller Joan W JW Vavvas Demetrios G DG
Proceedings of the National Academy of Sciences of the United States of America 20101122 50
Apoptosis has been shown to be a significant form of cell loss in many diseases. Detachment of photoreceptors from the retinal pigment epithelium, as seen in various retinal disorders, causes photoreceptor loss and subsequent vision decline. Although caspase-dependent apoptotic pathways are activated after retinal detachment, caspase inhibition by the pan-caspase inhibitor Z-VAD fails to prevent photoreceptor death; thus, we investigated other pathways leading to cell loss. Here, we show that re ...[more]