Alzheimer's disease peptide beta-amyloid interacts with fibrinogen and induces its oligomerization.
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ABSTRACT:
SUBMITTER: Ahn HJ
PROVIDER: S-EPMC3003082 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
Alzheimer's disease peptide beta-amyloid interacts with fibrinogen and induces its oligomerization.
Ahn Hyung Jin HJ Zamolodchikov Daria D Cortes-Canteli Marta M Norris Erin H EH Glickman J Fraser JF Strickland Sidney S
Proceedings of the National Academy of Sciences of the United States of America 20101122 50
Increasing evidence supports a vascular contribution to Alzheimer's disease (AD), but a direct connection between AD and the circulatory system has not been established. Previous work has shown that blood clots formed in the presence of the β-amyloid peptide (Aβ), which has been implicated in AD, have an abnormal structure and are resistant to degradation in vitro and in vivo. In the present study, we show that Aβ specifically interacts with fibrinogen with a K(d) of 26.3 ± 6.7 nM, that the bind ...[more]
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