Blood amyloid-? oligomerization associated with neurodegeneration of Alzheimer's disease.

ABSTRACT: INTRODUCTION:Oligomeric amyloid-ß is a major toxic species associated with Alzheimer's disease pathogenesis. Methods used to measure oligomeric amyloid-? in the blood have increased in number in recent years. The Multimer Detection System-Oligomeric Amyloid-? (MDS-OA?) is a specific method to measure oligomerization tendencies in the blood. The objective of this study was to determine the association between amyloid-ß oligomerization in the plasma and structural changes of the brain. METHODS:We studied 162 subjects composed of 92 community-based normal healthy subjects, 17 with subjective cognitive decline, 14 with mild cognitive impairment and 39 with Alzheimer's disease dementia. All subjects underwent MDS-OA? and three-dimensional T1 magnetic resonance imaging. To determine the structural changes of the brain that are statistically correlated with MDS-OA? level, we used voxel-based morphometry with corrections for age and total intracranial volume covariates. RESULTS:We found brain volume reduction in the bilateral temporal, amygdala, parahippocampal and lower parietal lobe and left cingulate and precuneus regions (family-wise error, p?

SUBMITTER: Youn YC 

PROVIDER: S-EPMC6511146 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature