Target-seeking antifibrotic compound enhances wound healing and suppresses scar formation in mice.

ABSTRACT: Permanent scars form upon healing of tissue injuries such as those caused by ischemia (myocardial infarction, stroke), trauma, surgery, and inflammation. Current options in reducing scar formation are limited to local intervention. We have designed a systemically administered, target-seeking biotherapeutic for scar prevention. It consists of a vascular targeting peptide that specifically recognizes angiogenic blood vessels and extravasates into sites of injury, fused with a therapeutic molecule, decorin. Decorin prevents tissue fibrosis and promotes tissue regeneration by inhibiting TGF-β activity and by other regulatory activities. The decorin-targeting peptide fusion protein had substantially increased neutralizing activity against TGF-β1 in vitro compared with untargeted decorin. In viv

SUBMITTER: Jarvinen TA 

PROVIDER: S-EPMC3003105 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature