Ontology highlight
ABSTRACT:
SUBMITTER: Streit M
PROVIDER: S-EPMC313956 | biostudies-literature | 2000 Jul
REPOSITORIES: biostudies-literature
Streit M M Velasco P P Riccardi L L Spencer L L Brown L F LF Janes L L Lange-Asschenfeldt B B Yano K K Hawighorst T T Iruela-Arispe L L Detmar M M
The EMBO journal 20000701 13
The function of the endogenous angiogenesis inhibitor thrombospondin-1 (TSP-1) in tissue repair has remained controversial. We established transgenic mice with targeted overexpression of TSP-1 in the skin, using a keratin 14 expression cassette. TSP-1 transgenic mice were healthy and fertile, and did not show any major abnormalities of normal skin vascularity, cutaneous vascular architecture, or microvascular permeability. However, healing of full-thickness skin wounds was greatly delayed in TSP ...[more]