Ontology highlight
ABSTRACT:
SUBMITTER: LeBoeuf M
PROVIDER: S-EPMC3003338 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
LeBoeuf Matthew M Terrell Anne A Trivedi Sohum S Sinha Satrajit S Epstein Jonathan A JA Olson Eric N EN Morrisey Edward E EE Millar Sarah E SE
Developmental cell 20101118 6
Epidermal and hair follicle development from surface ectodermal progenitor cells requires coordinated changes in gene expression. Histone deacetylases alter gene expression programs through modification of chromatin and transcription factors. We find that deletion of ectodermal Hdac1 and Hdac2 results in dramatic failure of hair follicle specification and epidermal proliferation and stratification, phenocopying loss of the key ectodermal transcription factor p63. Although expression of p63 and i ...[more]