Ontology highlight
ABSTRACT:
SUBMITTER: Schaedler S
PROVIDER: S-EPMC3003406 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Schaedler Stephanie S Krause Janis J Himmelsbach Kiyoshi K Carvajal-Yepes Monica M Lieder Franziska F Klingel Karin K Nassal Michael M Weiss Thomas S TS Werner Sabine S Hildt Eberhard E
The Journal of biological chemistry 20101018 52
The expression of a variety of cytoprotective genes is regulated by short cis-acting elements in their promoters, called antioxidant response elements (AREs). A central regulator of ARE-mediated gene expression is the NF-E2-related factor 2 (Nrf2). Human hepatitis B virus (HBV) induces a strong activation of Nrf2/ARE-regulated genes in vitro and in vivo. This is triggered by the HBV-regulatory proteins (HBx and LHBs) via c-Raf and MEK. The Nrf2/ARE-mediated induction of cytoprotective genes by H ...[more]