Integrin-mediated function of Rab GTPases in cancer progression.
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ABSTRACT:
SUBMITTER: Subramani D
PROVIDER: S-EPMC3003658 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
Integrin-mediated function of Rab GTPases in cancer progression.
Subramani Dhatchayini D Alahari Suresh K SK
Molecular cancer 20101209
The RAS (rat sarcoma) superfamily of small GTPases is broadly subdivided into five groups: Ras, Rho, Rab, Ran, and Arf. Rab family proteins are important in regulating signal transduction and cellular processes such as differentiation, proliferation, vesicle transport, nuclear assembly, and cytoskeleton formation. However, some Rab proteins have been reported to be necessary for the adhesion and migration of cancer cells. Although Ras and Rho family members have been strongly implicated in cance ...[more]
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