Rab GTPases in Osteoclastic Endomembrane Systems.
Ontology highlight
ABSTRACT:
SUBMITTER: Roy M
PROVIDER: S-EPMC6114073 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Rab GTPases in Osteoclastic Endomembrane Systems.
BioMed research international 20180815
Osteoclasts (OCs) are bone-resorbing cells that maintain bone homeostasis. OC differentiation, survival, and activity are regulated by numerous small GTPases, including those of the Rab family, which are involved in plasma membrane delivery and lysosomal and autophagic degradation pathways. In resorbing OCs, polarized vesicular trafficking pathways also result in formation of the ruffled membrane, the resorbing organelle, and in transcytosis. ...[more]
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