Ontology highlight
ABSTRACT:
SUBMITTER: Parker MD
PROVIDER: S-EPMC3004303 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Parker Michael D MD Buckley Marilyn J MJ Melanson Vanessa R VR Glass Pamela J PJ Norwood David D Hart Mary Kate MK
Journal of virology 20101006 24
Six monoclonal antibodies were isolated that exhibited specificity for a furin cleavage site deletion mutant (V3526) of Venezuelan equine encephalitis virus (VEEV). These antibodies comprise a single competition group and bound the E3 glycoprotein of VEEV subtype I viruses but failed to bind the E3 glycoprotein of other alphaviruses. These antibodies neutralized V3526 virus infectivity but did not neutralize the parental strain of Trinidad donkey (TrD) VEEV. However, the E3-specific antibodies d ...[more]