Dataset Information

Characteristics of lymphocyte subsets in HIV-infected, long-term nonprogressor, and healthy Asian children through 12 years of age.

ABSTRACT:

Background

There are limited data on the immune profiles of HIV-positive children compared with healthy controls, and no such data for Asian children.

Objectives

To immunophenotype HIV-positive Asian children, including long-term nonprogressors (LTNPs), compared with age-matched healthy controls.

Methods

We used flow cytometry to analyze 13 lymphocyte and monocyte subsets from 222 untreated, HIV-positive children with 15% to 24% CD4(+) T cells and no AIDS-related illnesses and 142 healthy children (controls). Data were compared among age categories. Profiles from LTNPs (n = 50), defined as children ?8 years old with CD4(+) T-cell counts ?350 cells/mm(3), were compared with data from age-matched non-LTNPs (n = 17) and controls (n = 53).

Results

Compared with controls, HIV-positive children had lower values (cell count per mm(3) and percent distribution) for T(H) cells and higher values for cytotoxic T cells, with reductions in populations of naive T(H) and cytotoxic T cells, B cells, and natural killer (NK) cells. HIV-positive children had high values for activated T(H) and cytotoxic T cells. Compared with non-LTNPs, LTNPs had higher values of T(H) and cytotoxic T cells, naive and memory T-cell subsets, and B and NK cells. Surprisingly, counts of activated T(H) and cytotoxic T cells were also higher among LTNPs. LNTPs were more frequently male.

Conclusion

Untreated, HIV-infected Asian children have immune profiles that differ from those of controls, characterized by low values for T(H) cells, naive T cells, B cells, and NK cells but high values for cytotoxic, activated T(H), and cytotoxic T cells. The higher values for activated T cells observed in LTNPs require confirmation in longitudinal studies.

SUBMITTER: Ananworanich J

PROVIDER: S-EPMC3004741 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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Publications

Characteristics of lymphocyte subsets in HIV-infected, long-term nonprogressor, and healthy Asian children through 12 years of age.

Ananworanich Jintanat J Apornpong Tanakorn T Kosalaraksa Pope P Jaimulwong Tanyathip T Hansudewechakul Rawiwan R Pancharoen Chitsanu C Bunupuradah Torsak T Chandara Mom M Puthanakit Thanyawee T Ngampiyasakul Chaiwat C Wongsawat Jurai J Kanjanavanit Suparat S Luesomboon Wicharn W Klangsinsirikul Phennapha P Ngo-Giang-Huong Nicole N Kerr Stephen J SJ Ubolyam Sasiwimol S Mengthaisong Tawan T Gelman Rebecca S RS Pattanapanyasat Kovit K Saphonn Vonthanak V Ruxrungtham Kiat K Shearer William T WT

The Journal of allergy and clinical immunology 20101201 6

<h4>Background</h4>There are limited data on the immune profiles of HIV-positive children compared with healthy controls, and no such data for Asian children.<h4>Objectives</h4>To immunophenotype HIV-positive Asian children, including long-term nonprogressors (LTNPs), compared with age-matched healthy controls.<h4>Methods</h4>We used flow cytometry to analyze 13 lymphocyte and monocyte subsets from 222 untreated, HIV-positive children with 15% to 24% CD4(+) T cells and no AIDS-related illnesses ...[more]

PMID: 21134574

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Dataset Information

Characteristics of lymphocyte subsets in HIV-infected, long-term nonprogressor, and healthy Asian children through 12 years of age.

Background

Objectives

Methods

Results

Conclusion

Publications

Characteristics of lymphocyte subsets in HIV-infected, long-term nonprogressor, and healthy Asian children through 12 years of age.

Similar Datasets

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