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A general glycomimetic strategy yields non-carbohydrate inhibitors of DC-SIGN.


ABSTRACT: Shikimic acid can be transformed into monovalent and multivalent glycomimetics that target different members of the C-type lectin class, including DC-SIGN, a dendritic cell lectin that facilitates HIV transmission.

SUBMITTER: Garber KC 

PROVIDER: S-EPMC3005762 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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A general glycomimetic strategy yields non-carbohydrate inhibitors of DC-SIGN.

Garber Kathleen C A KC   Wangkanont Kittikhun K   Carlson Erin E EE   Kiessling Laura L LL  

Chemical communications (Cambridge, England) 20100818 36


Shikimic acid can be transformed into monovalent and multivalent glycomimetics that target different members of the C-type lectin class, including DC-SIGN, a dendritic cell lectin that facilitates HIV transmission. ...[more]

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