Ontology highlight
ABSTRACT:
SUBMITTER: Medve L
PROVIDER: S-EPMC6899773 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Medve Laura L Achilli Silvia S Guzman-Caldentey Joan J Thépaut Michel M Senaldi Luca L Le Roy Aline A Sattin Sara S Ebel Christine C Vivès Corinne C Martin-Santamaria Sonsoles S Bernardi Anna A Fieschi Franck F
Chemistry (Weinheim an der Bergstrasse, Germany) 20191018 64
Chemical modification of pseudo-dimannoside ligands guided by fragment-based design allowed for the exploitation of an ammonium-binding region in the vicinity of the mannose-binding site of DC-SIGN, leading to the synthesis of a glycomimetic antagonist (compound 16) of unprecedented affinity and selectivity against the related lectin langerin. Here, the computational design of pseudo-dimannoside derivatives as DC-SIGN ligands, their synthesis, their evaluation as DC-SIGN selective antagonists, t ...[more]