Ontology highlight
ABSTRACT:
SUBMITTER: Varela-Rohena A
PROVIDER: S-EPMC3008216 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Varela-Rohena Angel A Molloy Peter E PE Dunn Steven M SM Li Yi Y Suhoski Megan M MM Carroll Richard G RG Milicic Anita A Mahon Tara T Sutton Deborah H DH Laugel Bruno B Moysey Ruth R Cameron Brian J BJ Vuidepot Annelise A Purbhoo Marco A MA Cole David K DK Phillips Rodney E RE June Carl H CH Jakobsen Bent K BK Sewell Andrew K AK Riley James L JL
Nature medicine 20081109 12
HIV's considerable capacity to vary its HLA-I-restricted peptide antigens allows it to escape from host cytotoxic T lymphocytes (CTLs). Nevertheless, therapeutics able to target HLA-I-associated antigens, with specificity for the spectrum of preferred CTL escape mutants, could prove effective. Here we use phage display to isolate and enhance a T-cell antigen receptor (TCR) originating from a CTL line derived from an infected person and specific for the immunodominant HLA-A(*)02-restricted, HIVga ...[more]