Ontology highlight
ABSTRACT:
SUBMITTER: Iglesias MC
PROVIDER: S-EPMC3162351 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Iglesias Maria Candela MC Almeida Jorge R JR Fastenackels Solène S van Bockel David J DJ Hashimoto Masao M Venturi Vanessa V Gostick Emma E Urrutia Alejandra A Wooldridge Linda L Clement Mathew M Gras Stéphanie S Wilmann Pascal G PG Autran Brigitte B Moris Arnaud A Rossjohn Jamie J Davenport Miles P MP Takiguchi Masafumi M Brander Christian C Douek Daniel C DC Kelleher Anthony D AD Price David A DA Appay Victor V
Blood 20110706 8
Mapping the precise determinants of T-cell efficacy against viruses in humans is a public health priority with crucial implications for vaccine design. To inform this effort, we performed a comprehensive analysis of the effective CD8(+) T-cell clonotypes that constitute responses specific for the HIV p24 Gag-derived KK10 epitope (KRWIILGLNK; residues 263-272) restricted by HLA-B*2705, which are known to confer superior control of viral replication in HIV-infected individuals. Particular KK10-spe ...[more]