Ontology highlight
ABSTRACT:
SUBMITTER: Bathe F
PROVIDER: S-EPMC3008270 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Bathe Friederike F Kempf Claudia C Osmani Stephen A SA Osmani Aysha H AH Hettinger Sabrina S Wohlmann Elke E Fischer Reinhard R
Eukaryotic cell 20101015 12
Cdk9-like kinases in complex with T-type cyclins are essential components of the eukaryotic transcription elongation machinery. The full spectrum of Cdk9/cyclin T targets, as well as the specific consequences of phosphorylations, is still largely undefined. We identify and characterize here a Cdk9 kinase (PtkA) in the filamentous ascomycete Aspergillus nidulans. Deletion of ptkA had a lethal effect in later stages of vegetative growth and completely impeded asexual development. Overexpression of ...[more]