Ontology highlight
ABSTRACT:
SUBMITTER: Brewster CD
PROVIDER: S-EPMC3008307 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Virology 20101109 2
Walleye dermal sarcoma virus encodes a retroviral cyclin (rv-cyclin) with a cyclin box fold and transcription activation domain (AD). Co-immune precipitation (co-IP) identified an association of rv-cyclin with cyclin-dependent kinase 8 (cdk8). Cdk8 is dependent upon cyclin C and regulates transcription with the Mediator complex, a co-activator of transcription. Mutation of cyclin residues, required for cdk binding, disrupts rv-cyclin-cdk8 co-IP. Mutation or removal of the AD has no effect on cdk ...[more]