Ontology highlight
ABSTRACT:
SUBMITTER: Bennett EJ
PROVIDER: S-EPMC3008586 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Bennett Eric J EJ Rush John J Gygi Steven P SP Harper J Wade JW
Cell 20101201 6
Dynamic reorganization of signaling systems frequently accompanies pathway perturbations, yet quantitative studies of network remodeling by pathway stimuli are lacking. Here, we report the development of a quantitative proteomics platform centered on multiplex absolute quantification (AQUA) technology to elucidate the architecture of the cullin-RING ubiquitin ligase (CRL) network and to evaluate current models of dynamic CRL remodeling. Current models suggest that CRL complexes are controlled by ...[more]