Ontology highlight
ABSTRACT:
SUBMITTER: Hoyo C
PROVIDER: S-EPMC3008656 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Hoyo Cathrine C Schildkraut Joellen M JM Murphy Susan K SK Chow Wong-Ho WH Vaughan Thomas L TL Risch Harvey H Marks Jeffrey R JR Jirtle Randy L RL Calingaert Brian B Mayne Susan S Fraumeni Joseph J Gammon Marilie D MD
International journal of cancer 20091201 11
The mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encodes a protein that plays a critical role in tumor suppression, in part by modulating bioavailability of a potent mitogen, insulin-like growth factor-2 (IGF2). We tested the hypothesis that the common nonsynonymous genetic variants in M6P/IGF2R c.901C > G (Leu > Val) in exon 6 and c.5002G > A (Gly > Arg) in exon 34 are associated with risk of esophageal and gastric cancers. Study participants in this population-based st ...[more]