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Prognostic impact of Claudin 18.2 in gastric and esophageal adenocarcinomas.

ABSTRACT: INTRODUCTION:The tight junction molecule Claudin 18.2 is selectively expressed in healthy and malignant gastric epithelial tissue and is a promising therapy target for high Claudin 18.2 expressing adenocarcinomas of the esophagogastric junction and stomach (AEG/S). METHODS:This study analyzed the prevalence, characteristics and prognostic impact of Claudin 18.2 expression in primary tumor, lymph node and distant metastasis in a large Caucasian AGE/S cohort with 414 patients. RESULTS:Claudin 18.2 was highly expressed in 17.1% of primary tumors, 26.7% of lymph node metastasis and 16.7% of distant metastasis. High Claudin 18.2 expression in lymph node metastasis and primary tumors correlated significantly (p?

SUBMITTER: Arnold A

PROVIDER: S-EPMC7577914 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Prognostic impact of Claudin 18.2 in gastric and esophageal adenocarcinomas.

Arnold A A Daum S S von Winterfeld M M Berg E E Hummel M M Rau B B Stein U U Treese C C

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20200601 12

<h4>Introduction</h4>The tight junction molecule Claudin 18.2 is selectively expressed in healthy and malignant gastric epithelial tissue and is a promising therapy target for high Claudin 18.2 expressing adenocarcinomas of the esophagogastric junction and stomach (AEG/S).<h4>Methods</h4>This study analyzed the prevalence, characteristics and prognostic impact of Claudin 18.2 expression in primary tumor, lymph node and distant metastasis in a large Caucasian AGE/S cohort with 414 patients.<h4>Re ...[more]

PMID: 32488802

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