Ontology highlight
ABSTRACT:
SUBMITTER: Cossu F
PROVIDER: S-EPMC3009409 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Cossu Federica F Malvezzi Francesca F Canevari Giulia G Mastrangelo Eloise E Lecis Daniele D Delia Domenico D Seneci Pierfausto P Scolastico Carlo C Bolognesi Martino M Milani Mario M
Protein science : a publication of the Protein Society 20101201 12
Inhibitor of apoptosis proteins (IAPs) are negative regulators of apoptosis. As IAPs are overexpressed in many tumors, where they confer chemoresistance, small molecules inactivating IAPs have been proposed as anticancer agents. Accordingly, a number of IAP-binding pro-apoptotic compounds that mimic the sequence corresponding to the N-terminal tetrapeptide of Smac/DIABLO, the natural endogenous IAPs inhibitor, have been developed. Here, we report the crystal structures of the BIR3 domain of cIAP ...[more]