Ontology highlight
ABSTRACT:
SUBMITTER: Cheung HH
PROVIDER: S-EPMC3122057 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Cheung H H HH St Jean M M Beug S T ST Lejmi-Mrad R R LaCasse E E Baird S D SD Stojdl D F DF Screaton R A RA Korneluk R G RG
Cell death & disease 20110414
Smac mimetic compounds (SMCs) are experimental small molecules that induce tumour necrosis factor alpha (TNFα)-dependent cancer cell death by targeting the inhibitor of apoptosis proteins. However, many cancer cell lines are resistant to SMC-mediated apoptosis despite the presence of TNFα. To add insight into the mechanism of SMC-resistance, we used functional siRNA-based kinomic and focused chemical screens and identified suppressor of morphogenesis in genitalia-1 (SMG1) and NF-κB-inducing kina ...[more]