Ontology highlight
ABSTRACT:
SUBMITTER: Xu Y
PROVIDER: S-EPMC3009588 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Xu Yanping Y Shin Hyeon-Gyu HG Szép Szilvia S Lu Zhe Z
Nature structural & molecular biology 20091115 12
Strong voltage sensitivity of inward-rectifier K(+) (Kir) channels has been hypothesized to arise primarily from an intracellular blocker displacing up to five K(+) ions from the wide, intracellular part of the ion conduction pore outwardly across the narrow ion-selectivity filter. The validity of this hypothesis depends on two assumptions: (i) that five ion sites are located intracellular to the filter and (ii) that the blocker can force essentially unidirectional K(+) movement in a pore region ...[more]