Ontology highlight
ABSTRACT:
SUBMITTER: Kvansakul M
PROVIDER: S-EPMC3009601 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Kvansakul Marc M Wei Andrew H AH Fletcher Jamie I JI Willis Simon N SN Chen Lin L Roberts Andrew W AW Huang David C S DC Colman Peter M PM
PLoS pathogens 20101223 12
Epstein-Barr virus (EBV) is associated with human malignancies, especially those affecting the B cell compartment such as Burkitt lymphoma. The virally encoded homolog of the mammalian pro-survival protein Bcl-2, BHRF1 contributes to viral infectivity and lymphomagenesis. In addition to the pro-apoptotic BH3-only protein Bim, its key target in lymphoid cells, BHRF1 also binds a selective sub-set of pro-apoptotic proteins (Bid, Puma, Bak) expressed by host cells. A consequence of BHRF1 expression ...[more]