Ontology highlight
ABSTRACT:
SUBMITTER: Gunther S
PROVIDER: S-EPMC3009805 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Günther Sebastian S Schlundt Andreas A Sticht Jana J Roske Yvette Y Heinemann Udo U Wiesmüller Karl-Heinz KH Jung Günther G Falk Kirsten K Rötzschke Olaf O Freund Christian C
Proceedings of the National Academy of Sciences of the United States of America 20101129 51
T-cell recognition of peptides bound to MHC class II (MHCII) molecules is a central event in cell-mediated adaptive immunity. The current paradigm holds that prebound class II-associated invariant chain peptides (CLIP) and all subsequent antigens maintain a canonical orientation in the MHCII binding groove. Here we provide evidence for MHCII-bound CLIP inversion. NMR spectroscopy demonstrates that the interconversion from the canonical to the inverse alignment is a dynamic process, and X-ray cry ...[more]