Ontology highlight
ABSTRACT:
SUBMITTER: Koch N
PROVIDER: S-EPMC3043101 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
PloS one 20110222 2
<h4>Background</h4>The HLA gene complex encodes three class II isotypes, DR, DQ, and DP. HLA class II molecules are peptide receptors that present antigens for recognition by T lymphocytes. In antigen presenting cells, the assembly of matched α and β subunits to heterodimers is chaperoned by invariant chain (Ii). Ii forms a homotrimer with three binding sites for class II heterodimers. The current model of class II and Ii structure states that three αβ heterodimers bind to an Ii trimer.<h4>Metho ...[more]