Ontology highlight
ABSTRACT:
SUBMITTER: Spessott W
PROVIDER: S-EPMC3009873 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Spessott Waldo W Uliana Andrea A Maccioni Hugo J F HJ
The Journal of biological chemistry 20101103 53
The COG (conserved oligomeric Golgi complex) is a Golgi-associated tethering complex involved in retrograde trafficking of multiple Golgi enzymes. COG deficiencies lead to misorganization of the Golgi, defective trafficking of glycosylation enzymes, and abnormal N-, O- and ceramide-linked oligosaccharides. Here, we show that in Cog2 null mutant ldlC cells, the content of sphingomyelin (SM) is reduced to ∼25% of WT cells. Sphingomyelin synthase (SMS) activity is essentially normal in ldlC cells, ...[more]