Ontology highlight
ABSTRACT:
SUBMITTER: Tian L
PROVIDER: S-EPMC4202124 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Tian Lifeng L Wang Chenguang C Hagen Fred K FK Gormley Michael M Addya Sankar S Soccio Raymond R Casimiro Mathew C MC Zhou Jie J Powell Michael J MJ Xu Ping P Deng Haiteng H Sauve Anthony A AA Pestell Richard G RG
Oncotarget 20140901 17
In our prior publications we characterized a conserved acetylation motif (K(R)xxKK) of evolutionarily related nuclear receptors. Recent reports showed that peroxisome proliferator activated receptor gamma (PPARγ) deacetylation by SIRT1 is involved in delaying cellular senescence and maintaining the brown remodeling of white adipose tissue. However, it still remains unknown whether lysyl residues 154 and 155 (K154/155) of the conserved acetylation motif (RIHKK) in Pparγ1 are acetylated. Herein, w ...[more]