Ontology highlight
ABSTRACT:
SUBMITTER: Martinez-Barriocanal A
PROVIDER: S-EPMC3009906 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Martínez-Barriocanal Agueda A Comas-Casellas Emma E Schwartz Simo S Martín Margarita M Sayós Joan J
The Journal of biological chemistry 20101019 53
The CD300 family of myeloid immunoglobulin receptors includes activating (CD300b, CD300e) and inhibitory members (CD300a, CD300f), as well as molecules of uncertain function presenting a negative charge within their transmembrane domain (CD300c, CD300d). In this paper, we establish that CD300c is a functional immune receptor able to deliver activating signals upon ligation in RBL-2H3 mast cells. CD300c signaling is partially mediated by a direct association with the immune receptor tyrosine-base ...[more]