Ontology highlight
ABSTRACT:
SUBMITTER: Foldi J
PROVIDER: S-EPMC3010732 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Foldi Julia J Chung Allen Y AY Xu Haixia H Zhu Jimmy J Outtz Hasina H HH Kitajewski Jan J Li Yueming Y Hu Xiaoyu X Ivashkiv Lionel B LB
Journal of immunology (Baltimore, Md. : 1950) 20100924 9
Several signaling pathways, including the Notch pathway, can modulate TLR activation to achieve responses most appropriate for the environment. One mechanism of TLR-Notch cross-talk is TLR-induced expression of Notch ligands Jagged and Delta that feed back to engage Notch receptors on TLR-activated cells. In this study, we investigated mechanisms by which TLRs induce Notch ligand expression in primary macrophages. TLRs induced Jagged1 expression rapidly and independently of new protein synthesis ...[more]