Ontology highlight
ABSTRACT:
SUBMITTER: Pelullo M
PROVIDER: S-EPMC4309263 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Pelullo Maria M Quaranta Roberta R Talora Claudio C Checquolo Saula S Cialfi Samantha S Felli Maria Pia MP te Kronnie Geertruy G te Kronnie Geertruy G Borga Chiara C Besharat Zein Mersini ZM Palermo Rocco R Di Marcotullio Lucia L Capobianco Anthony J AJ Gulino Alberto A Screpanti Isabella I Bellavia Diana D
Neoplasia (New York, N.Y.) 20141201 12
Deregulated Notch signaling has been extensively linked to T-cell acute lymphoblastic leukemia (T-ALL). Here, we show a direct relationship between Notch3 receptor and Jagged1 ligand in human cell lines and in a mouse model of T-ALL. We provide evidence that Notch-specific ligand Jagged1 is a new Notch3 signaling target gene. This essential event justifies an aberrant Notch3/Jagged1 cis-expression inside the same cell. Moreover, we demonstrate in Notch3-IC-overexpressing T lymphoma cells that Ja ...[more]