Unknown

Dataset Information

0

A highly selective and general palladium catalyst for the oxidative Heck reaction of electronically nonbiased olefins.


ABSTRACT: A general, highly selective oxidative Heck reaction is reported. The reaction is high-yielding under mild conditions without the need for base or high temperatures, and the selectivity is excellent, without the requirement for electronically biased olefins or other specific directing groups. A preliminary mechanistic investigation suggests that the unusually high selectivity may be due to the catalyst's sensitivity to C-H bond strength in the selectivity-determining ?-hydride elimination step.

SUBMITTER: Werner EW 

PROVIDER: S-EPMC3011814 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

A highly selective and general palladium catalyst for the oxidative Heck reaction of electronically nonbiased olefins.

Werner Erik W EW   Sigman Matthew S MS  

Journal of the American Chemical Society 20101001 40


A general, highly selective oxidative Heck reaction is reported. The reaction is high-yielding under mild conditions without the need for base or high temperatures, and the selectivity is excellent, without the requirement for electronically biased olefins or other specific directing groups. A preliminary mechanistic investigation suggests that the unusually high selectivity may be due to the catalyst's sensitivity to C-H bond strength in the selectivity-determining β-hydride elimination step. ...[more]

Similar Datasets

| S-EPMC3124000 | biostudies-literature
| S-EPMC5813498 | biostudies-literature
| S-EPMC3740572 | biostudies-literature
| S-EPMC4159703 | biostudies-literature
| S-EPMC5618772 | biostudies-literature
| S-EPMC3993847 | biostudies-other
| S-EPMC7821284 | biostudies-literature
| S-EPMC5084063 | biostudies-literature
| S-EPMC5727777 | biostudies-literature
| S-EPMC9807023 | biostudies-literature