Ontology highlight
ABSTRACT:
SUBMITTER: Osteen JD
PROVIDER: S-EPMC3012494 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Osteen Jeremiah D JD Gonzalez Carlos C Sampson Kevin J KJ Iyer Vivek V Rebolledo Santiago S Larsson H Peter HP Kass Robert S RS
Proceedings of the National Academy of Sciences of the United States of America 20101213 52
The delayed rectifier I(Ks) potassium channel, formed by coassembly of α- (KCNQ1) and β- (KCNE1) subunits, is essential for cardiac function. Although KCNE1 is necessary to reproduce the functional properties of the native I(Ks) channel, the mechanism(s) through which KCNE1 modulates KCNQ1 is unknown. Here we report measurements of voltage sensor movements in KCNQ1 and KCNQ1/KCNE1 channels using voltage clamp fluorometry. KCNQ1 channels exhibit indistinguishable voltage dependence of fluorescenc ...[more]