Ontology highlight
ABSTRACT:
SUBMITTER: Sun X
PROVIDER: S-EPMC3013533 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Sun Xuming X Yang Li V LV Tiegs Brian C BC Arend Lois J LJ McGraw Dennis W DW Penn Raymond B RB Petrovic Snezana S
Journal of the American Society of Nephrology : JASN 20100826 10
Proton receptors are G protein-coupled receptors that accept protons as ligands and function as pH sensors. One of the proton receptors, GPR4, is relatively abundant in the kidney, but its potential role in acid-base homeostasis is unknown. In this study, we examined the distribution of GPR4 in the kidney, its function in kidney epithelial cells, and the effects of its deletion on acid-base homeostasis. We observed GPR4 expression in the kidney cortex, in the outer and inner medulla, in isolated ...[more]