Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC3014016 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Xu Jianyong J Li Huapeng H Wang Bo B Xu Yan Y Yang Jiayin J Zhang Xiaofei X Harten Sarah K SK Shukla Deepa D Maxwell Patrick H PH Pei Duanqing D Esteban Miguel A MA
Journal of the American Society of Nephrology : JASN 20100923 12
The ciliary hypothesis for cystic renal diseases postulates that most of these conditions result from abnormalities in the primary cilium, a microtubule-based structure that acts as a sensor for extracellular cues. Inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene predisposes to renal cysts and clear cell renal cell carcinoma. VHL plays a critical role in the formation of primary cilia in kidney epithelium, but the underlying mechanisms are poorly understood. Here, we demonstrate ...[more]