Ontology highlight
ABSTRACT:
SUBMITTER: Simard A
PROVIDER: S-EPMC3014603 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Simard Annie A Di Giorgio Luciano L Amen Melanie M Westwood Ashley A Amendt Brad A BA Ryan Aimee K AK
Developmental dynamics : an official publication of the American Association of Anatomists 20091001 10
The paired-like homeodomain transcription factor Pitx2c has an essential role in patterning the left-right axis. However, neither its transcriptional targets nor the molecular mechanisms through which it exerts its patterning function are known. Here we provide evidence that the N-terminal domain of Pitx2c is important for this activity. Overexpression of the Pitx2c N-terminus in ovo randomizes the direction of heart looping, the first morphological asymmetry conserved in vertebrate embryos. In ...[more]