Ontology highlight
ABSTRACT:
SUBMITTER: Movassaghi M
PROVIDER: S-EPMC3016719 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Chemical science 20100101
The pyrrole-imidazole family of marine alkaloids, derived from linear clathrodin-like precursors, constitutes a diverse array of structurally complex natural products. The bioactive agelastatins are members of this family that possess a tetracyclic molecular framework incorporating C4-C8 and C7-N12 bond connectivities. We provide a hypothesis for the formation of the unique agelastatin architecture that maximally exploits the intrinsic chemistry of plausible biosynthetic precursors. We report th ...[more]