Total Synthesis of Novel Skeleton Flavan-Alkaloids.
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ABSTRACT:
SUBMITTER: Zhen J
PROVIDER: S-EPMC7582810 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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Total Synthesis of Novel Skeleton Flavan-Alkaloids.
Zhen Jing J Simon James E JE Wu Qingli Q
Molecules (Basel, Switzerland) 20200930 19
The first total synthesis of novel skeleton natural compounds kinkeloids A and B, a group of newly discovered flavan alkaloids isolated from the African plant <i>Combretum micranthum</i>, are described in this study. The key and final step are achieved by Mannich reaction, through which the piperidine moiety couples to the flavan moiety. The identities of synthesized kinkeloids were further confirmed through a comparison with the ones in the plant leaves extract using LC/MS. ...[more]
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