Ontology highlight
ABSTRACT:
SUBMITTER: Rappas M
PROVIDER: S-EPMC3017600 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Nucleic acids research 20100819 1
TopBP1 is a scaffold protein that coordinates activation of the DNA-damage-checkpoint response by coupling binding of the 9-1-1 checkpoint clamp at sites of ssDNA, to activation of the ATR-ATRIP checkpoint kinase complex. We have now determined the crystal structure of the N-terminal region of human TopBP1, revealing an unexpected triple-BRCT domain structure. The arrangement of the BRCT domains differs significantly from previously described tandem BRCT domain structures, and presents two disti ...[more]